Reversible Diels–Alder and Michael Addition Reactions Enable the Facile Postsynthetic Modification of Metal–Organic Frameworks

Functionalization of metal–organic frameworks (MOFs) is critical in exploring their structural and chemical diversity for numerous potential applications. Herein, we report multiple approaches the tandem postsynthetic modification (PSM) various MOFs derived from Zr(IV), Al(III), Zn(II). Our current work based on our efforts to develop a wide range MOF platforms with dynamic functional nature that can be chemically switched via thermally triggered reversible Diels–Alder (DA) hetero-Diels–Alder (HDA) ligations. Furan-tagged (furan-UiO-66-Zr) were conjugated maleimide groups bearing dienophiles prepare switchable nature. As HDA pairs, phosphoryl dithioester-based moieties cyclopentadiene (Cp)-grafted (Cp-MIL-53-Al) utilized demonstrate cleavage rebonding linkages as function temperature. In addition these strategies, Michael reaction was also applied PSM IRMOF-3-Zn. Maleimide postsynthetically introduced lattice, which further ligated cysteine-based biomolecules thiol–maleimide reaction. On basis versatility herein presented chemistry, expect will help designing variety sophisticated materials addressing diverse